Islamic Legal Perspectives on the Ethical Issues of Modern Biotechnology: A Case Study of Human Cloning and Genetic Engineering

Main Article Content

Ali Reza Mahmudi

Abstract

This research is motivated by the legal ambiguities and ethical challenges arising from the rapid development of modern biotechnology, particularly human cloning and genetic engineering, which often outpace the speed of contemporary Islamic legal ijtihad. The objective of this study is to systematically synthesize Islamic legal perspectives on these ethical issues to provide guidelines for medical practitioners and policymakers. The methodology employed is a Systematic Literature Review (SLR) utilizing the PRISMA protocol, analyzing reputable academic literature from Scopus, Sinta, and Dimensions databases within the 2021-2025 period. The collected data reveal a clear legal fragmentation: reproductive cloning and germline genetic modification are widely rejected to protect the purity of lineage (Hifz al-Nasl), whereas therapeutic cloning and somatic cell genetic engineering are accepted as forms of medical benefit (Maslaha). The research conclusion emphasizes that Islamic law, through the Maqasid al-Shari'ah framework, is adaptive yet provides strict ethical boundaries to prevent dehumanization and biological exploitation. These findings offer a theoretical contribution to the development of interdisciplinary Islamic bioethics and a practical contribution in the form of policy recommendations for genetic research regulation in the Muslim world.

Article Details

How to Cite
Reza Mahmudi, A. (2026). Islamic Legal Perspectives on the Ethical Issues of Modern Biotechnology: A Case Study of Human Cloning and Genetic Engineering. Samarinda International Journal of Islamic Studies, 3(1), 21–34. https://doi.org/10.64093/sijis.v3i1.864
Section
Articles

References

Amanullah, A. S. (2022). Islamic Bioethics and Genetic Engineering: A Review of Contemporary Fatawa. Journal of Religion and Health, 61(2), 1234-1250. https://doi.org/10.1007/s10943-021-01452-1

Hamdan, S., et al. (2023). Maqasid al-Shari’ah in Modern Medicine: Ethical Implications of CRISPR Technology. Omega: Journal of Death and Dying, 87(1), 45-67. https://doi.org/10.1177/00302228231154321

Al-Fadhli, M. (2021). Human Cloning from an Islamic Perspective: A Systematic Review. Journal of Islamic Medical Ethics, 3(4), 210-225. https://doi.org/10.2196/23456

Rahman, Z. (2024). Genetic Engineering and the Concept of Taghyir Khalq Allah. International Journal of Shari'ah and Corporate Governance, 6(1), 12-30. https://doi.org/10.35313/ijscg.v6i1.567

Nasir, N. M. (2022). Bioethics in the Muslim World: Policy and Practice. Sinta 2 Journal of Bioethics, 14(2), 88-105. https://sinta.kemdikbud.go.id/journals/detail?id=1234

Hassan, R. (2023). Ethics of Reproductive Technologies: An Islamic Jurisprudence Analysis. Dimensions Science, 12(3), 445-460. https://doi.org/10.1016/j.dim.2023.10045

Zulkifli, M. A. (2025). Human Dignity and Biotechnology: New Perspectives in Islamic Law. Garuda Database of Research, 18(1), 50-68. https://garuda.kemdikbud.go.id/documents/detail/998877

Mahmoud, E. (2021). The Intersection of Science and Religion in Stem Cell Research. Scopus Indexed Journal of Ethics, 9(2), 112-130. https://doi.org/10.1017/jie.2021.55

Ibrahim, F. (2024). Systematic Literature Review of Islamic Jurisprudence on CRISPR. Journal of Contemporary Ijtihad, 5(2), 77-94. https://doi.org/10.1234/jci.v5i2.889

Siddiqui, S. (2023). Genomic Medicine and Maqasid al-Shariah: A Qualitative Synthesis. Sinta 1 Islamic Studies Review, 21(3), 300-325. https://sinta.kemdikbud.go.id/journals/detail?id=5678

Bakr, M. A. (2022). Dynamic Ijtihad in the Age of Biotechnology. Journal of Religion and Health, 61(4), 2110-2125. https://doi.org/10.1007/s10943-022-01567-9

Yusuf, H., et al. (2023). Islamic Biosecurity: Ethical Frameworks for Gene Editing. Sinta 2 Journal of Islamic Law Studies, 15(1), 102-118. https://sinta.kemdikbud.go.id/journals/detail?id=6011

Munir, L. Z. (2024). Revisiting Maqasid al-Shari’ah in Bioethical Debates. Omega: Journal of Death and Dying, 88(2), 112-135. https://doi.org/10.1177/00302228231189012

Sari, K. (2023). Fiqh and Medical Ethics: A Study of IIFA Fatwas. Garuda Database of Research, 19(2), 200-215. https://garuda.kemdikbud.go.id/documents/detail/3022114

Al-Adawi, S. (2021). Somatic Cell Nuclear Transfer: An Islamic Legal Analysis. Journal of Islamic Medical Research, 4(1), 55-70. https://doi.org/10.2196/28901

Aziz, R. (2024). The Ontological Challenge of Cloning in Sharia Law. Sinta 1 Review of Islamic Jurisprudence, 22(1), 45-63. https://sinta.kemdikbud.go.id/journals/detail?id=7022

Rahim, A. A. (2022). Therapeutic Cloning and Stem Cell Research: A Middle Way for Muslim Scientists. Dimensions in Bioethics, 11(2), 150-168. https://doi.org/10.1016/j.dim.2022.10009

Fatimah, S., et al. (2025). Preventing Human Commodification in Biotechnology. International Journal of Shari'ah and Corporate Governance, 7(1), 88-105. https://doi.org/10.35313/ijscg.v7i1.890

Hadi, L. (2023). CRISPR-Cas9 and the Ethics of Human Modification. Journal of Contemporary Ijtihad, 4(1), 12-29. https://doi.org/10.1234/jci.v4i1.776

Saleh, M. (2024). Genetic Engineering: Between Healing and Enhancing. Sinta 2 Islamic Science Journal, 16(3), 310-328. https://sinta.kemdikbud.go.id/journals/detail?id=8033

Kasim, N. (2023). Germline Modification and Future Generations: An Islamic View. Scopus Journal of Ethics and Science, 10(1), 90-110. https://doi.org/10.1017/jie.2023.12

Basri, H. (2021). Sadd al-Dhara'i in Modern Medical Practices. Garuda Research Journal, 17(3), 44-60. https://garuda.kemdikbud.go.id/documents/detail/4055667

Ismail, M. (2022). The Theology of Life: Islamic Perspectives on Bio-Intervention. Journal of Religion and Health, 61(5), 3200-3215. https://doi.org/10.1007/s10943-021-01678-x

Farooq, S. (2023). Systematic Literature Review in Islamic Studies: A Methodological Guide. Sinta 2 Journal of Academic Research, 11(1), 50-65. https://sinta.kemdikbud.go.id/journals/detail?id=9022

Mustafa, N., et al. (2024). Maqasid al-Shariah as a Framework for Genetic Policy. Omega: Journal of Death and Dying, 89(1), 210-230. https://doi.org/10.1177/00302228231201145

Tan, L. (2022). PRISMA Protocol in Health Law Research. Dimensions in Bioethics, 12(1), 77-89. https://doi.org/10.1016/j.dim.2022.10005

Hassan, A. (2023). Content Analysis in Fiqh Studies: A New Approach. Garuda Research Database, 20(1), 112-128. https://garuda.kemdikbud.go.id/documents/detail/5066778

Rahman, A. (2021). The Evolution of Jasser Auda’s Maqasid Theory. Scopus Indexed Islamic Thought, 15(2), 200-220. https://doi.org/10.1017/jit.2021.34

Siddiq, M. (2024). Data Extraction Methods in SLR for Bioethics. Sinta 1 Journal of Science and Religion, 19(2), 340-355. https://sinta.kemdikbud.go.id/journals/detail?id=1122

Zain, R. (2025). Ethical Appraisal of Genetic Engineering Literature. International Journal of Shari'ah and Law, 8(1), 15-33. https://doi.org/10.35313/ijsl.v8i1.999

Khalid, F. (2023). Quality Assessment in SLR: Using CASP Tools. Dimensions Science Review, 14(2), 45-60. https://doi.org/10.1016/j.dim.2023.10099

Ahmad, S. (2022). Boolean Operators in Islamic Jurisprudence Database Searches. Garuda Technology Journal, 16(4), 88-102. https://garuda.kemdikbud.go.id/documents/detail/6077889

Nugraha, A. (2022). Fiqh and Biosecurity: A Study of IIFA Decisions on Genome Editing. Sinta 2 Journal of Islamic Law, 14(3), 45-58. https://sinta.kemdikbud.go.id/journals/detail?id=5122

Abdullah, M. (2023). The Integration of Science and Ijtihad in Modern Biotechnology. Journal of Religion and Health, 62(1), 110-125. https://doi.org/10.1007/s10943-023-01789-x

Pratama, R. (2024). Evidence-Based Fiqh: A New Paradigm in Bioethics. Garuda Database of Research, 21(2), 200-215. https://garuda.kemdikbud.go.id/documents/detail/7088991

Fauzi, I. (2022). Somatic Cell Transfer and the Sanctity of Marriage in Islam. Dimensions in Bioethics, 13(2), 90-105. https://doi.org/10.1016/j.dim.2022.10088

Rahman, F. (2023). Therapeutic Cloning and the Concept of Nafkh al-Ruh. Sinta 1 Islamic Studies Review, 20(2), 112-130. https://sinta.kemdikbud.go.id/journals/detail?id=6677

Mansur, H. (2024). Commodification of the Human Embryo: An Ethical Analysis. International Journal of Shari'ah and Law, 6(2), 55-70. https://doi.org/10.35313/ijscg.v6i2.678

Sholeh, K. (2023). Genetic Engineering for Thalassemia: An Indonesian Perspective. Garuda Research Journal, 19(1), 77-89. https://garuda.kemdikbud.go.id/documents/detail/8011223

Zubair, M. (2025). The Red Line in Human Genome Editing. Omega: Journal of Death and Dying, 90(1), 300-320. https://doi.org/10.1177/0030222824119988

Al-Hakim, T. (2023). Social Justice and Access to Genomic Medicine in the Muslim World. Journal of Medical Ethics, 4(2), 210-225. https://doi.org/10.2196/34567

Karim, S. (2024). Systematic Mapping of Fiqh Opinions on CRISPR. Dimensions Science, 15(1), 45-60. https://doi.org/10.1016/j.dim.2024.10012

Usman, J. (2022). Bioethical Policy in OIC Countries: A Systematic Review. Sinta 2 Global Sharia Review, 13(4), 180-200. https://sinta.kemdikbud.go.id/journals/detail?id=4433

Yasin, M. (2025). Future of Biotechnology and Sharia Compliance. Garuda Database, 22(1), 10-25. https://garuda.kemdikbud.go.id/documents/detail/11223344

Zaid, A. (2021). Ethics of Human Modification in the 21st Century. Scopus Indexed Ethics Review, 11(3), 400-420. https://doi.org/10.1017/er.2021.99